MovDisordV3, Main, Exploration, bibRecord, 002607

Ten‐year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease

Identifieur interne : 002607 ( Main/Exploration ); précédent : 002606; suivant : 002608

Ten‐year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease

Auteurs : Andrea C. Solomon [États-Unis] ; Julie C. Stout [États-Unis, Australie] ; Marjorie Weaver [États-Unis] ; Sarah Queller [États-Unis] ; Allison Tomusk [États-Unis] ; Kathryn Burr Whitlock [États-Unis] ; Siu L. Hui [États-Unis] ; Jeanine Marshall [États-Unis] ; Jacqueline Gray Jackson [États-Unis] ; Eric R. Siemers [États-Unis] ; Xabier Beristain [États-Unis] ; Joanne Wojcieszek [États-Unis] ; Tatiana Foroud [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-10-15.

RBID : ISTEX:19A73E6DF19470CF91D5C385C3B54DF343837EEB

Descripteurs français

Pascal (Inist)
- Chorée de Huntington, Pathologie du système nerveux.

English descriptors

KwdEn :
- Adult, Age of Onset, Cognition (physiology), Female, Humans, Huntington Disease (diagnosis), Huntington Disease (genetics), Huntington Disease (physiopathology), Huntington disease, Longitudinal Studies, Male, Middle Aged, Motor Activity (physiology), Nervous system diseases, Neuropsychological Tests, Psychomotor Performance (physiology), Reaction Time (genetics), Severity of Illness Index, Trinucleotide Repeat Expansion (genetics), longitudinal, neurocognitive, prediagnosis.
MESH :
- diagnosis : Huntington Disease.
- genetics : Huntington Disease, Reaction Time, Trinucleotide Repeat Expansion.
- physiology : Cognition, Motor Activity, Psychomotor Performance.
- physiopathology : Huntington Disease.
- Adult, Age of Onset, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.

Abstract

Longitudinal studies of neurocognitive function in prediagnosis Huntington disease (pre‐HD) have been few, and duration of follow‐up has been brief. In this study, 155 individuals at‐risk for HD completed a battery of cognitive and motor tasks at two study visits ∼10 years apart. Participants were classified as: (1) at‐risk, without the CAG expansion (healthy controls, NC; n = 112), or (2) CAG expanded (CAG+; n = 43). To examine the rate of decline at different stages of the pre‐HD period, participants in the CAG+ group were further characterized as converters (i.e., individuals who developed manifest HD over the course of the study; n = 21) or nonconverters (n = 22), and their performances were compared. The CAG+ group exhibited faster rates of neurocognitive decline over the course of the study, relative to the NC group. In addition, more rapid decline was associated with closer proximity to estimated age of disease onset in the CAG+ group. Faster rates of motor and psychomotor decline were observed in the CAG+ converter group, relative to the nonconverters. These findings suggest that neurocognitive decline in pre‐HD, particularly in motor and psychomotor domains, begins insidiously and accelerates as individuals approach disease onset. © 2008 Movement Disorder Society

Url:

DOI: 10.1002/mds.22097

Affiliations:

Le document en format XML

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<term>Female</term>
<term>Humans</term>
<term>Huntington Disease (diagnosis)</term>
<term>Huntington Disease (genetics)</term>
<term>Huntington Disease (physiopathology)</term>
<term>Huntington disease</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (physiology)</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Psychomotor Performance (physiology)</term>
<term>Reaction Time (genetics)</term>
<term>Severity of Illness Index</term>
<term>Trinucleotide Repeat Expansion (genetics)</term>
<term>longitudinal</term>
<term>neurocognitive</term>
<term>prediagnosis</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term>
<term>Reaction Time</term>
<term>Trinucleotide Repeat Expansion</term>
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<term>Motor Activity</term>
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<term>Age of Onset</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Severity of Illness Index</term>
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<front><div type="abstract" xml:lang="en">Longitudinal studies of neurocognitive function in prediagnosis Huntington disease (pre‐HD) have been few, and duration of follow‐up has been brief. In this study, 155 individuals at‐risk for HD completed a battery of cognitive and motor tasks at two study visits ∼10 years apart. Participants were classified as: (1) at‐risk, without the CAG expansion (healthy controls, NC; n = 112), or (2) CAG expanded (CAG+; n = 43). To examine the rate of decline at different stages of the pre‐HD period, participants in the CAG+ group were further characterized as converters (i.e., individuals who developed manifest HD over the course of the study; n = 21) or nonconverters (n = 22), and their performances were compared. The CAG+ group exhibited faster rates of neurocognitive decline over the course of the study, relative to the NC group. In addition, more rapid decline was associated with closer proximity to estimated age of disease onset in the CAG+ group. Faster rates of motor and psychomotor decline were observed in the CAG+ converter group, relative to the nonconverters. These findings suggest that neurocognitive decline in pre‐HD, particularly in motor and psychomotor domains, begins insidiously and accelerates as individuals approach disease onset. © 2008 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Ten‐year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease

Ten‐year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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